This Week In Virology With Vincent Racaniello

TWiV reviews continuing expansion of poliovirus type 2, removal of influenza B/Yamagata from the vaccine, Nobel Prize for miRNAs, protective immune response with a adenovirus-associated virus vector expressing a computationally designed hemagglutinin, and viral gene drive during herpes simplex 1 infection in mice. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Continued expansion of type 2 poliovirus (reliefweb) No more polio case map at polioeradication.org B/Yamagata removed from flu vaccine (NPR) Nobel Prizes for miRNA (ScienceInsider) AAV-vectored influenza vaccine (J Virol) Herpesvirus type 1 gene drive in mice (Nat Commun) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Virus and Vaccines Information Page from NIH All of Us Research Program Kathy – For a Pivotal Vaccine: Trial, Error and Two Young Lives Rich – October 17 20

In his weekly clinical update, Dr. Griffin informs us about mpox circulation, the Marburg virus outbreak in Rwanda, new recommendations for the RSV and pneumococcal vaccines by the CDC, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, what the risk of SARS-CoV-2 transmission is when indoors, the difference between NVX-CoV2327 and BNT162b2 for adolescents, why 65 years and older should get a second boost of the COVID-19 vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, the clinical trial for evaluating how novel treatments of COVID-19 affect long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome after SARS-CoV-2 infection. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Grim marker: mpox over a 1000 deaths in Africa (CIDRAP) Global trend of mpox outbreak 2022-2024 (WH

Vincent travels to the Karolinska Institute in Stockholm to meet up with Niklas Björkström and Joakim Dillner to review their research on the endometrial immune system, and the plan to eliminate cervical cancer in Sweden. Host: Vincent Racaniello Guests: Niklas Björkström and Joakim Dillner Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Endometrial immune system variation (Sci Immunol) Immune defense in the womb (News from Karolinska) HPV vaccination and screening for elimination (Nat Comm) Cervical cancer elimination strategies (Int J Cancer) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin informs us about mpox circulation and new vaccine approval, the Marburg virus outbreak in Rwanda, and the largest outbreak of whooping cough in a decade before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunity among those over 65th following the 3rd dose of the COVID-19 mRNA vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, how well the SARS-CoV-2 rapid antigen test performed, what do when healthcare workers succumb to SARS-CoV-2 infection, the effect of remdesivir on survival and readmission of hospitalized patients, if cognitive impairment following virus infection impairs one’s driving and how long COVID affects Chinese society. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Undiagnosed MPXV infections are high in men who have sex with men (BMC Infectious Diseases) WHO, now a vaccine approval agency, Jynneos for teens  (CIDRA

TWiV reviews Marburg virus outbreak in Rwanda, cryo-EM based discovery of a parvovirus causing black wasting disease in farmed beetles, and a mosaic nanoparticle experimental vaccine that elicits cross-reactive sarbecovirus responses in pre-vaccinated animals. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Marburg virus disease, Rwanda (WHO) Suspected German Marburg case tests negative (Politico) Cryo-EM discovery of insect parvovirus (Cell) Mosaic sarbecovirus nanoparticle experimental vaccine (Cell) Letters read on TWiV 1157 Timestamps by Jolene. Thanks! Weekly Picks Brianne – ASM Lesson Plans Alan – A City on Mars, and this blog by a ham radio operator hit by Hurricane Helene Vincent – How to Win A Nobel Prize Listener Pick Laura – Science of Public Communication (original article) Intro music is by Ronald Jenkees Send your virology questions and comments to t

In his weekly clinical update, Dr. Griffin updates us about polio SIA campaign in Gaza, the durability of protection following administration of GSK’s recombinant antigen RSV vaccine, mpox in an Ugandan jail, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunogenicity, reactogenicity and safety of different COVID-19 vaccine platforms, disease severity in those not previously vaccinated with those vaccinated but not infected, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if COVID-19 doubles the risk for heart attacks, stroke and death and if COVID-19 affects the regions of the brainstem. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Polio: second round of vaccination in Gaza (Reuters) Season 3 for GSK RSV vaccine protection (CIDRAP) Positive data for Arexvy, the respirato

TWiV reviews mask effectiveness against respiratory infections, EEE death in NY State, viruses with zoonotic potential in farmed fur animals, and genetic tracing of market wild life and viruses at the Huanan Seafood Market, the epicenter of the COVID-19 pandemic. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Review confirms mask effectiveness (original article) EEE death in Ulster County NY (CBS News) EEE on TWiV 1145 Viruses of farmed fur animals (Nature) Tracing of wildlife and viruses at COVID-19 epicenter (Cell) Letters read on TWiV 1155 Timestamps by Jolene. Thanks! Weekly Picks Rich – Immunize.org, Vaccineinformation.org, National Network of Immunization Coalitions Alan – Birdcast Vincent – A universal framework for inclusive 15-minute cities Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast

In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, the lack of immune durability elicited by mRNA vaccine and the finding of how SARS-CoV-2 infection impacts memory, cognition and reduces grey matter volume. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rwanda: Marburg virus disease (WHO) Passport required?…..Marburg virus commutes to Germany (CIDRAP) Outbreak of whooping cough/pertussis…..no lifelong immunity following vaccination? (Bloomberg Pr

From the Viruses of Microbes meeting in Cairns, Australia, TWiV speaks with Krystyna and Rob about their research on using bacteriophages to treat bacterial infections. Hosts: Vincent Racaniello and Jolene Ramsey Guests: Krystyna Dabrowska and Rob Lavigne Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Viruses of Microbes 2024 Immune responses to phages (Front Immunol) Engineering bacteriolytic enzymes (Front Immunol) 100 cases of phage therapy (Nat Micro) Synthetic biology potential of bacteriophages (Nat Micro) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Waning vaccine protection against mpox…..isn’t this the way the humoral immune response works? (CIDRAP) 1:46 Uncontrollable mpox outbreak in Africa  (Reuters) 4:10 Antibodies elicited by the Jynneos vaccine against mpox contract after 6-9 months….can

TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Polio vaccination in Gaza (Reuters) Zoonotic viruses in farmed fur animals (Nature) HPV vaccination and cancer rates (JAMA Net Open) 40 kb RNA genome without error correction (PNAS) Stopping the phage tape measure protein (Nat Commun) Tail assembly interference (Nat Commun) Letters read on TWiV 1151 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Digital nature pics winners 2024 Wildlife Photographer of the Year Alan – Adorable story about a Nigerian paralympian couple who are

In his weekly clinical update, Dr. Griffin dives into West Nile virus in New Jersey, poliovirus vaccination campaign in Gaza and Afghanistan, California dengue virus infections, children dying from flu, mpox vaccination procurement and antiviral usage, flu circulation in US, before reviewing the recent statistics on SARS-CoV-2 infection, finding a new wasterwater dashboard, if the monovalent XBB.1.5 COVID-19 vaccine is effective against circulating SARS-CoV-2 isolates, the need for nasal mucosal IgA in response to SARS-CoV-2 infection, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravir treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if those taking the anti-diabetic drug metformin have higher or lower in

From the annual meeting of the American Society for Virology, Kathy and Brianne speak with Mary Estes about her career and the research of her laboratory on viruses that infect the gastrointestinal tract, including rotavirus and norovirus. Hosts: Kathy Spindler and Brianne Barker Guest: Mary Estes Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Diarrhea induced by rotavirus NSP4 (Science) Minimal infective dose of rotavirus (Arch Virol) mRNA release from rotavirus particles (Nat Struct Biol) Norovirus vaccine (Clin Ther) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin dives into “pandemic potential” viruses isolated from farmed fur animals, how the mRNA and pox vectored vaccines against mpox spar against each other, how telehealth does managing mpox, and if prophylactic use of the anti-RSV monoclonal for infants is cost-effective before reviewing the recent statistics on SARS-CoV-2 infection, if viral load correlates to one vaccination status, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravirs treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if SARS-CoV-2 during Omicron alters ones’ micriobiota. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Lending you the viru

TWiV reviews multi-country outbreak of Mpox, first face covering ban in Nassau County NY, case of polio in India, more in US accept vaccine misinformation, other wartime diseases in Gaza besides polio, a new scientist run virus genome database, Mpox epidemiology and vaccine effectiveness in England, and metabolic immaturity and breastmilk bile acid metabolites determine heightened newborn vulnerability to norovirus diarrhea. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Multi-country Mpox outbreak (WHO) Face covering ban in Nassau County (NBC) Polio case in India (Business Standard) More acceptance of vaccine misinformation (EurekAlert) War in Gaza not just causing polio (Jerusalem Post) Scientist run virus genome database (Science) Mpox epidemiology and vaccine effectiveness (Emerg Inf Dis) Newborn vulnerability to norovirus diarrhea (Cell Host Microbe) Times

In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, how fibrin drives thromboinflammation and neuropathology in COVID-19, and an evidence based approach to long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Recommendations for seasonal influenza prevention and vaccines (MMWR) Gaza: poliovirus RNA in sewage water (Reuters) Success of the polio vaccination campaign in Gaza (Reuters) UNICEF-Gavi-WO-Africa CDC securing mpox vaccines (Gavi) mpox vaccine tend

TWiV reviews a case of polio in Gaza, more Mpox, COVID-19 boosters, effectiveness of Ebola virus vaccine, measles cases across the US, an endogenous retroviral envelope protein that regulates human cardiomyocyte development, and submergence of an encephalitic alphavirus caused by receptor shifts. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Gaza baby has polio (Times Israel) Monkeypox virus clade Ib in Thailand (CIDRAP) Updated COVID-19 vaccines (FDA) Effectiveness of Ebola virus vaccine (Lancet Inf Dis) Measles cases in Georgia, Oregon (CIDRAP) Retrovirus protein regulates cardiomyocyte development (Cell Stem Cell) Receptor shifts govern submergence of encephalitis arbovirus (Nature)   Letters read on TWiV 1145 Timestamps by Jolene. Thanks! Weekly Picks Kathy – Googlegangers and AWWW clip Rich – RP FLIP (floating instrument platform) Alan – Big

In his weekly clinical update, Dr. Griffin discusses Dr. Fauci’s case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a pa

TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mpox outbreak is PHEIC (WHO) Tecovirimat not great against monkeypox virus clade I (NIH) Case of Mpox Clade I in Sweden (PHAS) Mpox and pets in USA (Emerg Inf Dis) SARS-CoV-2 widespread in wildlife communities (Nat Comm) Salivary GAPDH benefits plant virus transmission (Nat Comm) Letters read on TWiV 1143 Timestamps by Jolene. Thanks! Weekly Picks Dickson – NASA Confirms Evidence That Liquid Water Flows on Today’s Mars Kathy – T

In his weekly clinical update, Dr. Griffin discusses global transmission of mpox, the different clades of the virus and associated pathogenesis, vaccination vs antiviral therapy against mpox and the US’s aid response for controlling the African outbreak before reviewing the recent statistics on SARS-CoV-2 infection, authorization and approval of updated COVID vaccines, the economic benefit of an annual COVID vaccine and if the first updated vaccines against XBB.1.5 were effective, where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and how long COVID differs in children and adolescents. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode mpox epidemic caused by monkeypox clade I in affected African countries (European Centre for Disease Prevention and Control) mpox in Pakistan (Reuters) mpox imported into Pakistan (UNMC Global C