Dr. Howard Smith Oncall

Vidcast: https://youtu.be/HKIK6qwIJo8 One enduring challenge in human organ transplantation is detecting rejection crises early enough to save the transplanted organ with the administration of anti-rejection drugs such as high dose steroids.  Typically, rejection is diagnosed with biopsies. By the time a biopsy shows conclusive changes, much of the organ is often destroyed.  A new technique being developed at the Georgia Institute of Technology may change all that. The diagnostic tool employs nanotechnology to build an ingenious probe that acts as an early warning beacon for organ rejection.  It is a nanoball with iron oxide in the middle, a sugar coating of dextran,  and some polyethylene glycol or antifreeze to prevent the body from quickly degrading it.  The ball is covered with amino acid florescent spikes.  These nanoballs are injected into the transplanted organs and remain there. As the transplant patient’s T cells bulk up to mount a rejection of a heart, liver, or kidney, they begin to produce the tox