Informações:
Sinopsis
Life science is complicated, but its mission is simple – to create a safer, healthier future. This podcast tells the stories behind the science from the perspective of patients, scientists, employees, and advocates that have felt its impact.
Episodios
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Retrogenix: The Screen Door of Drug Development
21/06/2022 Duración: 19minDrug developers face long odds and complex regulatory challenges when it comes to crafting a suitable candidate. In fact, only one of every 10 drug candidates gain regulatory approval, and when they do, it takes an average of 14 years and costs well over $2 billion. So what makes for a successful candidate? It starts with a suitable screening platform that identifies targets and the molecules that bind to them to create a therapeutic response. Retrogenix is one such platform that the top 20 drug developers in the world currently use to increase their chances of success thanks to its unique technology that doesn’t require animal models or human tissue to evaluate effectiveness. Join us to find out how Retrogenix works to identify targets, accelerate drug development, get vulnerable patients the therapies they need more quickly, and adapt to meet the growing demands of regulatory agencies. Show Notes Charles River Acquires Retrogenix Retrogenix Cell Microarray Technology De-risking Therapies and Vacci
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Open Science: The Parallel Universe
17/05/2022 Duración: 28minAled Edwards’ vision of science is set to shake the foundation of drug discovery and development as we know it. The Director of M4K Pharma and CEO of the Structural Genomics Consortium is leading the charge for a more open scientific approach. It’s a parallel universe where scientists can work together and get therapies designed to treat rare diseases in the hands of patients even faster – one that isn’t bound by patents, siloes, and profits. Join Aled as he discusses the “open science” approach, the current state of the pharmaceutical industry, and what the future holds for genetic biology.Show Notes M4K Pharma Open Science for Children's Health Structural Genomics Consortium The Disruptors - Meet Aled A Deadly Brain Cancer in Children Tackling DIPG with Open Science The Journal of Medicinal Chemistry—Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma Resources M4K Pharma Open Science for Children's H
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(Re)programming Stem Cells for Drug Development
19/04/2022 Duración: 27minA medic by trade, Mark Kotter has always held a particular interest in neuroscience and stem cell research.As founder and CEO of bit.bio, he's overseen the development of a unique approach to "reprogram" stem cells and change them into consistent and scalable disease-relevant cells, which can then be screened for potential therapeutics to help treat such diseases as Huntington's Alzheimer's, and ALS.Hear about this revolutionary technology and how it works, what benefits it can provide researchers, and how it could very well shape the future of drug development.Show Notes Stem Cells for Drug Discovery Building a Stable of Stem Cells Conversations in Science With Disruptors Leading the Way Neuroscience | Charles River bit.bio Resources https://www.bit.bio/news/focus-on-a-founder-with-mark-kotter-celebrating-10-years-of-community https://www.criver.com/eureka/podcast/e28-building-the-building-blocks-of-life https://www.criver.com/about-us/disruptors/meet-mark?region=3601 https://www.bit.bio/
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Are we One Shot Away?
15/03/2022 Duración: 21minImagine a gene therapy treatment that gives drug-resistant focal epilepsy patients more control over their seizures and ultimately improve their quality of life?We sat down with Karin Agerman to discuss this possibility and discovered that her work at Combigene is at the forefront of a novel gene therapy called CG01.Find out how this single-injection therapy is giving renewed hope to this patient population and learn more about CombiGene’s research into CG01.SHOW NOTES Cell and Gene Therapy Services and Products CombiGene Gene Therapy, A Promising Future for Epileptic Drug Development High Quality Plasmid DNA: A Case for Phase Dependent Approaches to Manufacturing Tailored Preclinical Support for Your Cell & Gene Therapies Digital Resources Cell and Gene Therapy Development Video Series Charles River Completes the Acquisition of Cognate BioServices CombiGene initiates GMP production of CG01 for the first-in-human study Navigating the ATMP Regulatory Landscape
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From Humble Beginnings to Potential Treatment for ALS
18/01/2022 Duración: 33minIn March 2020, we invited Josh Cohen and Justin Klee on Vital Science to discuss Amylyx Pharmaceuticals, a company that had one simple mission – to improve the quality of life for those battling neurodegenerative diseases. Since their humble beginnings, what was once a company with less than ten employees has grown exponentially. Get the latest from Josh and Justin as they rejoin our podcast to discuss the new drug application process for AMX0035, what they’ve learned from their experiences, and what lies ahead. See what Amylyx Pharmaceuticals is currently working on and get updates on clinical trials.
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Donors: The Unsung Heroes Advancing Science
21/12/2021 Duración: 15minThe role of human cells and tissues is key in the development of next-generation therapies. With just a few samples, donors contribute to scientific advancements in medicine. This is especially true with cell and gene therapy, a field that is projected to grow over the next several years, and with it comes the growing need to find reliable and recallable donors willing to help those in need. In our latest episode of Vital Science, learn more about the critical role these unsung heroes play in advancing the future of therapeutic development. Show Notes The Link Between a Consistent Cell Supply and Successful Cell Therapies A Reliable Donor Network is the Foundation for Development of Successful Cell-Based Therapies What Impacts Starting Material Quality? Part 1: Donor Variability Developing Cell Therapies? Donors Matter. Resources Hemacare Cell and Gene Therapy Services and Products
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Can MILs Strike a Killer Blow to Cancer?
19/10/2021 Duración: 28minFrom a young age, Kim Noonan knew what she wanted in life — a career in science and a desire to help.When her mother succumbed to gastric cancer, it drove her even more to help people, especially cancer patients. Today, she’s at the forefront of a potentially game-changing development in cancer therapy — using bone marrow-infiltrating lymphocytes (MILs) designed to target and kill cancerous tumors of all shapes and sizes.Find out how her early work with myeloma patients started her road to discovering MILs, the origin of WindMIL Therapeutics, challenges associated with manufacturing MIL-based therapies, and what the future holds for this revolutionary treatment.Learn more about WindMIL Therapeutics and the science behind their work with bone marrow immunology.SHOW NOTES Cell and Gene Therapy Services Oncology Research and Drug Development The Link Between a Consistent Cell Supply and Successful Cell Therapies Charles River Presents: Tailored Preclinical Support for Your Cell & Gene Therapies Cell and Gene
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A Synergistic Approach to Treating Huntington’s Disease
21/09/2021 Duración: 32minHuntington’s disease may only affect one in every 10,000 people in the United States, but its symptoms can drastically debilitate a person’s quality of life.For Ignacio Muñoz-Sanjuan, he witnessed first-hand the devastating effects this disease can have. He’s visited parts of the world that have the highest prevalence of Huntington’s disease on the planet, including Taiwan and South America. Today, he’s involved with two different nonprofit organizations seeking to accelerate the development of treatments to help those afflicted by, or at risk for, this fatal condition.Join us as we explore Ignacio Muñoz-Sanjuan’s journey in raising awareness about Huntington’s disease, how Charles River contributed to developing a framework for potential treatments, and what he believes the future holds for drug development in this disease area.Discover how the CHDI Foundation and Factor-H are working to help those suffering from Huntington’s disease and how you can get involved. Huntington’s Disease (HD) Studies DNA Dama
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Opening Treatments
20/07/2021 Duración: 38minSanath Ramesh was determined to track down the resources needed to repurpose a drug for his son Raghav’s ultra-rare disease. This determination led him to apply his experiences and empower the rare disease community with his collaborative platform, the OpenTreatments Foundation. Find out how his repurposed drug platform is now giving hope to other rare disease patients.EPISODE LINKOTHER RESOURCES: Open Treatments Repurposing Compound Libraries High-Throughput Screening
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Standing on the Shoulders of Giants
15/06/2021 Duración: 30minWhat if it was possible to speed up drug development without having to reinvent the wheel? By repurposing existing drugs, drug hunters are taking a giant step forward towards changing the future of drug discovery. Join our panel of drug hunters to hear how they reinvent previously approved drugs to get a head start towards treating patients. Acknowledgements: Hosted by: Chris GarciaNarrated by: Gina Mullane and Chris Garcia Special thanks to: Ian WaddellVad LazariBarbara Killian
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Can a Repurposed Drug Be the Answer?
18/05/2021 Duración: 46minWhat if the cure for your untreatable disease was just waiting on the shelf at your neighborhood pharmacy? Join physician, patient, and researcher Dr. David Fajgenbaum as he shares how his unexpected battle with Castleman disease set him on a journey to find his cure and develop new ways of using existing drugs. Acknowledgements: Hosted by: Chris GarciaNarrated by: Gina Mullane Special thanks to: Dr. David FajgenbaumBarbara Killian
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The Life (Saving) Blood of Horseshoe Crabs
20/04/2021 Duración: 43minOur panel explores the vital role horseshoe crabs play in bacterial endotoxin testing and the ongoing battle to preserve the population.
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3D Cell Models: A Blueprint for Drug Development
16/03/2021 Duración: 28minHow are 3D cell models changing our ability to create more effective therapies? Our panel of scientific experts discuss.
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Driving Drug Development with CRISPR/Cas9
16/02/2021 Duración: 26minDr. David Fischer joins our panel to discuss the evolution, application, and potential of CRISPR/Cas9 gene editing technology.
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Get the Series Recap: Vaccines
19/01/2021 Duración: 03minIn this brief recap, our hosts Gina Mullane and Chris Garcia discuss topics covered in our series on vaccines.
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COVID-19 Vaccines – Behind the Scenes
15/12/2020 Duración: 20minDr. Sarah Gould returns to provide an update on the development of a vaccine for COVID-19 and what lies ahead.
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Beyond the Headlines: Understanding Accelerated Vaccines
17/11/2020 Duración: 23minDistinguished scientist Dr. Lauren Black discusses a “weight-of-evidence” approach to accelerated vaccine development and approvals.
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A Formidable Defense Against Infectious Diseases
20/10/2020 Duración: 46minDr. Christina Satterwhite delves into the immune system and how vaccines target harmful pathogens.
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Infectious Disease and The Rise of Vaccines
22/09/2020 Duración: 19minDr. Sarah Gould explains how infectious disease spurred the discovery and subsequent evolution of vaccines.
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Two in the Same
21/07/2020 Duración: 41minTwo sisters share their experience with clinical trials for cystic fibrosis.